Effects of p53 and ATRX inhibition on telomeric recombination in aging fibroblasts
In order to avoid replicative senescence, tumor cells must acquire a telomere maintenance mechanism.Beside Hob Panel Clip telomerase activation, a minority of tumors employs a recombinational mechanism called Alternative Lengthening of Telomeres (ALT).Several studies have investigated the potential ALT stimulation by inactivation of ATRX in tumor c